Single-dose treatment of gonorrhoea with cotrimoxazole. A report on 1,223 cases.
نویسنده
چکیده
1,223 ambulant patients with gonorrhoea were each treated with a single dose of eight tablets of cotrimoxazole. 1,069 patients were followed up (794 males and 275 females). Of these, only 46 (4%) failed to respond. Cotrimoxazole in the dosage used was well tolerated by all the patients, with very few side-effects. There was clear evidence that cotrimoxazole did not mask concomitant syphilitic infections; neither did it produce a gonococcal carrier state. The incidence of post-gonococcal non-specific urethritis was 6 per cent. At present cotrimoxazole seems to be the most useful alternative to penicillin in the treatment of gonorrhoea.
منابع مشابه
Treatment of gonorrhoea with cotrimoxazole, procaine penicillin alone, and procaine penicillin plus probenecid.
Successful treatment of gonorrhoea with cotri-moxazole* has now been reported by several workers who gave one tablet four times a day for 5 days, observed a failure rate of 38 per cent. of the 86 men followed. They claimed that in 45 per cent. of the failures a carrier state resulted which was detected by routine examination of Gram-stained smears in all cases after treatment; cultures were not...
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While penicillin remains the drug of choice in the treatment of gonorrhoea, the increasing incidence of strains of gon:cocci less sensitive to penicillin makes the contfnued search for other effective antibiotics of the greatest importance. Ideally, all treatments should be able to be given at one attendance, whether by injection or orally. Doxycycline hydrochloride (Vibramycin) in a single ora...
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Introduction & Objective: Urinary tract infections (UTI) are a common cause of morbidity and its diagnosis and treatment can lead to health. In this study we evaluated the efficacy of the long- term low-dose antibiotic prophylaxis with Cotrimoxazole and Nalidixic-acid in the patients with recurrent UTI. Materials & Methods: This study is a before and after clinical trial without control grou...
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The efficacy of single-agent chemotherapy for patients with low risk gestational trophoblastic neoplasia (LRGTN) with methotrexate or dactinomycin is well established, but efforts continue to reduce the toxicity, the patients time and cost of treatment. In a randomized clinical trial, we evaluated and compared the efficacy, toxicity and cost effectiveness of pulse-methotrexate versus pulse-dact...
متن کاملCost-effectiveness of management strategies for acute urethritis in the developing world.
OBJECTIVE To recommend a cost-effective approach for the management of acute male urethritis in the developing world, based on the findings of a theoretical study. METHODS A model was developed to assess the cost-effectiveness of three urethritis management strategies in a theoretical cohort of 1000 men with urethral syndrome. (1) All patients were treated with cefixime and doxycycline for go...
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ورودعنوان ژورنال:
- The British journal of venereal diseases
دوره 51 3 شماره
صفحات -
تاریخ انتشار 1975